Demystifying the Complexity of hCG complex: A Comprehensive Guide

hCG is the simple abbreviation for the Human Chorionic Gonadotropin hormone. If you find mention of Chorigon, Chorigon-10, Novarel; Ovidrel, Pregnyl, A.P.L, Profasi, Chorex; they possibly would mean the same hormone.

HCG Diet Products Are Illegal

An hCG Complex is a liquid version of the supplement to be taken as drops under the tongue for treatment of obesity. It’s aclaimed as a 100% natural formula, hCG Complex was developed as a formula along with hCG dietary method.

Dr. A.T.W. Simeons, a British endocrinologist, was one who originally discovered and researched on obesity and the impact of hCG hormone and hCG diet.

Under the banner of dietary supplements, the company called BioSource Labs develops hCG Complex. The company claims the product to be complying with FDA rules and guidelines, and GMP (Good and Manufacturing practice) standards.

Let’s take a pause here.  If weight loss is the real intent and of interest to the readers, it would be worthwhile for us to understand the related cause and effect, and the underlying genesis.

What is hCG?

hCG is a protein hormone. In 1905, two British physiologists Ernest Starling and William Bayliss were the first to identify and extract this special hormone found in the sample of the urine of pregnant women.

If any doctor were to congratulate women with good news; it is because of the pregnancy report showing up an elevated level of hCG count. In other words, when women trying to conceive miss a period and undergo a variety of pregnancy test made available in the market, they point to one and the same thing; which is a presence of 25 MIU/mL (Read as milli-international units per milliliter) or more of hCG and would be considered a positive test.

Here we want to stop digressing into hardcore medical details. We are all aware, how weight regulation connects closely with increased metabolism or lack of it. The intriguing connection that exists between weight loss and hCG connects to regulating metabolism, and that’s what we are trying to establish or debate!

Before that, any layman with some knowledge of biology would appreciate that human chorionic gonadotropin, or hCG, is a hormone to support female ovulation.  So, while low hCG impacts the ovulation process and maybe one of the possible causes of infertility; research has also shown that hCG has a corresponding positive correlation to Testosterone level. In other words, hCG helps stimulate testosterone levels in males.

The lack of testosterone or its imbalance and possible effects is a detailed subject. Low testosterone is also called male hypogonadism. Fundamentally the male reproductive glands do not produce enough testosterone (a male sex hormone).

Low testosterone impacts and manifests health conditions in multiple ways. One such condition is seen in many premature born boys – that is the condition of undescended testicles, meaning either one or both testicles are absent in the scrotum.

And Testosterone Replacement Therapy (TRT) is one of the possible ways that can help undescended testicles in young males to make it descend. But then, there is a natural reduction connected to the ageing process in adult men where we experience lower testosterone levels.

Briefly, a lack of testosterone means the following:

  • Increased body fat and obesity tendencies
  • Comparable low muscular strength
  • Low sex drive
  • Erectile dysfunction
  • Low on well-being
  • Depression
  • Difficulties with concentration and memory
  • Fatigue
  • Moodiness and irritability

Other changes that occur with low testosterone include:

  • A decrease in hemoglobin and mild anemia
  • A decrease in body hair
  • Thinning of the bones (Osteoporosis)
  • Breast development (Gynecomastia)
  • Infertility

Since our entire focus is around weight loss or correcting obesity, here we will limit our discussion to the following areas:

  1. What is the scientific correlation between hCG and Testosterone levels?
  2. How Testosterone and corresponding metabolism is connected?
  3. hCG weight loss program.
  4. What is the hCG diet?
  5. If the hCG diet is a low-calorie diet, isn’t it automatically supposed to benefit burning fat naturally?
  6. What are the pros and cons of the hCG complex?

Scientific Correlation Between hCG and Testosterone Level

I have been asked about the connection between hCG and Testosterone. But before that, let us understand the role of Luteinizing hormone (LH).  Luteinizing hormone (LH) is also known as lutropin or lutrophin.

As explained in the diagram below, Gonadotropin-releasing hormone (GNRH) is secreted from the hypothalamus and stimulates gonadotropic cells in the anterior pituitary gland. The stimulation releases luteinizing hormone and follicle-stimulating hormone, which in turn regulates the gametogenic (development of sex cells ) and steroidogenic (production of steroids, as by the adrenal cortex, testes, and ovaries) functions of the gonads (testes & Ovaries) in male and female.

In females, the rise of LH triggers ovulation and development of the corpus luteum. In males, LH stimulates Leydig cells. And what are Leydig cells? Leydig cells are found adjacent to the seminiferous tubules in the testicle, and it produces testosterone in the presence of Luteinizing hormone (LH).

Demystifying the Complexity of hCG complex: A Comprehensive Guide 1

Coming Back to hCG

My detailed research tells me that hCG and LH are glycoproteins, which means that these hormones are made up of a protein with a sugar attached to it. Many times we are unable to distinguish between LH and hCG in urine during the standard ovulation test. And that’s because they bind to a common receptor, the LH/choriogonadotropin receptor (LHCGR), also known as the LH or lutropin receptor (LHR).

Evidence suggests that hCG (Human Chorionic Gonadotropin), ends up mimicking the effects of Luteinizing Hormone (LH), which plays a vital role in the synthesis and secretion of testosterone. Thus, hCG can be utilized to treat male infertility or hypogonadism.

The below graph shows the secretion level of hCG and LH in normal male; thereby proving a strong +ve correlation

Demystifying the Complexity of hCG complex: A Comprehensive Guide 2

What are the other similarities? The molecular structure is also the same.

But do they cause a similar impact? Although they bind to a common receptor, new evidence suggests that LH and hCG have disparate effects on downstream signaling in the cascading system. And thus, these hormones are not interchangeable. The significance of differences between LH and hCG are getting realized, and more research is getting done to understand its expression and function.

Example: Reference to a case study of the patient with low sperm count and testosterone reveals a condition known as hypogonadotropic hypogonadism (HH). The patient is monitored for a measured dosage of Gonadotropin therapy with human chorionic gonadotropin and recombinant FSH. The results were greatly encouraging since the mean testosterone level went from 2.6 to 24.7 in 12 weeks. So much so that, this case had been able to father a child.

This patient had a good response to this treatment. However, his testosterone level and semen quality began to decline soon after stopping gonadotropin therapy, necessitating the need for testosterone replacement therapy after that.

Testosterone Levels and Metabolism

Testosterone drives muscle growth, and the relationship between testosterone and muscle growth is like a positive feedback loop. The more muscle mass we have in our body, the higher testosterone levels we will have, and the higher our testosterone levels, the more muscle we will build.

It is proven that men struggling with obesity are also accompanied with type2 diabetes and have low sex hormone-binding globulin (SHBG). Conversely, low testosterone and SHBG predict the development of metabolic syndrome and type 2 diabetes. Visceral adipose present in men with low testosterone, and type 2 diabetes only augment this.

The diagram below reflects this theory.

Testosterone Levels and MetabolismTestosterone Levels and MetabolismTestosterone Levels and MetabolismTestosterone Levels and MetabolismTestosterone Levels and Metabolism

Eureka! hCG’s indirect impact was indeed a fantastic find, to break into this vicious cycle of low testosterone and all sorts of defects; be it low sperm level or be it high visceral fat or be it associated perils like cardiovascular or diabetic problems.

hCG Weight Loss Program

‘Amazing hCG Weight Loss Cure Simplified’ is the book in which British Endocrinologist Albert T W Simeons had first explained the role of hCG.

He goes on to explain that there are three types of fat. First, the structural fat also called the organ fat, which provides cushion to the organs filling up space around them like bedding. The second type of fat is the fat reserved all over the body to draw nutrition from whenever there is a shortage. Both structural and reserve fat are packed compactly in the body and don’t contribute to obesity.

The third type is called abnormal fat, which acts like a safe deposit and is rarely tapped into to burn for energy. This abnormal fat is the cause of suffering for overweight people.

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Excessive dieting causes depletion of normal and reserve fat, giving the skin and hair a sallow look and keeping the body in constant fatigue. But the abnormal fat, which is the adipose tissue, remains untouched causing less weight loss than expected.

Dr. Simeons wanted something aggressive and goal-oriented. He wanted the patient to lose almost 1 pound a day without any significant impact of fatigue appearing on the patient. He defined a protocol lasting six to nine weeks starting with hCG injections for initial two-three days which prevents the body from accumulating fat initially and then limiting the diet to 500 calories for four weeks along with 25 to 40 doses of hCG injection. The treatment claims a weight loss of targeted one pound a week before moving to the last phase where the subject needs to maintain a new targeted weight and maintain a calorie of 1500 to 2000 based on the nature of the workload.

During the course, Dr. Simeons also found out that there was no loss in muscle mass. Dr. Siemons found that the release of fat/calories into the bloodstream did not make the patient hungry and generally provided plenty of energy, with hCG assisted injections. Finally, the levels of testosterone increase are found in patients with fewer secretions, and those with normal levels remained so, deterring any negative impact.

What is The hCG Diet?

Simeons suggested what he preferred to call the hCG diet. This is an extremely restrictive diet wherein the dieter takes only 500 calories a day. The nature of food includes asparagus, celery, green salad, spinach, cabbage, chard, red radishes, chicory, beet greens, tomatoes, cucumbers, fennel, and onions for vegetarians and 100-gram serving of chicken breast, shrimp, lobster, veal, beef, crab, or fresh white fish for non-vegetarian. There are in fact meal plans which we will not dwell out in detail now.

What is hCG Complex?

Based on Dr. Simeons’ study, many companies started a drive to produce hCG in various forms. Of these, the US-based company BioSource produces drops containing hCG complex. These are considered safe for daily use. They are to be consumed and not injected. The company claims to have FDA approval for these. However, FDA desists from cross-checking such claims.

Why is it Called hCG Complex?

The word ‘complex’ appears similar to elixir formulation. The company, BioSource, has put forth hCG complex drops as an ideal combination of 25 ingredients. Some of the prominent ingredients are:

  • Ginseng: an overall health enhancer, often used in alternative medicines.
  • L-Arginine: proven to improve muscle mass and cut fat.
  • L-Carnitine: believed to help in energy production at the cellular level.
  • L-Ornithine: increases fat metabolism during endurance exercise.
  • L-Lysine: reduces fatigue and helps suppress appetite.
  • Glutamic Acid: helps in energy production and fat oxidation.

Claimed Advantages of Using hCG Complex

  • hCG complex has natural ingredients and amino acids listed on its label.
  • It claims to have no really serious side-effects.
  • Since it is not a prescription drug, no doctor’s referral is needed.
  • The drops are reasonably priced.
  • Consuming is easier than injecting.

Disadvantages of Using hCG Complex

  • Its efficacy is not scientifically proven. And this is its major drawback.
  • A strict diet regime is to be followed along for results.
  • Diet and exercise still play a vital role in bringing any major change in the body.


The science fraternity may be divided in its views about the usage of hCG. A small group of researchers did not get substantial results, as claimed by Simeons. The repeated complaints forced the FDA to direct Simeons and others to put a disclaimer on their products.

On the other hand, some experts feel that hCG-induced body goes into a self-detox, thereby cleansing its system. Even the hypothalamus responds to this system and sends appropriate signals to the body. This not only aids weight loss but also improves overall wellbeing by reducing the risk of lifestyle diseases. What more can one want?

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